A diagnostic microdosing approach to investigate platinum sensitivity in non-small cell lung cancer
نویسندگان
چکیده
منابع مشابه
Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer
BACKGROUND The objective of this study was to evaluate the effect of platinum-based drugs on nuclear-factor erythroid2 like 2 (NRF2) signaling in non-small cell lung cancer cell lines with or without Kelch-like ECH-associated protein 1 (KEAP1) mutations and to determine the role of NRF2 and KEAP1 on platinum-based drug treatment. METHODS We used real-time PCR to assess relative mRNA expressio...
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Cisplatin-based chemotherapy remains the backbone in the treatment of non-small-cell lung cancer (NSCLC), with significantly improved survival and better quality of life [1]. Platinum based doublets, with new drugs like Gemcitabine, Vinorelbine and Taxanes, are superior to single agent chemotherapy and should be preferred in first line treatment of patients with advanced NSCLC, according to cur...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2017
ISSN: 0020-7136
DOI: 10.1002/ijc.30747